PACE invites applications for a full-time Associate Professor / Group Leader position to join a vibrant and interdisciplinary research environment entirely focused on clinical and basic biological aspects of Parkinson’s disease and other synucleinopathies. The successful candidate will establish a collaborative research program in longitudinal in vivo investigation of neuronal dysfunction and circuitry changes in rodent models of progressive synucleinopathies using cutting edge technologies. Thereby, the candidate will complement and contribute to ongoing research in our established research groups investigating the spreading of alpha-synuclein aggregates and their functional and tissue-level impacts using histological, transcriptomic, behavioral, and in vivo PET imaging approaches in rodent models.
To achieve our goal, we are seeking a group leader with a focus on understanding the neurophysiological and behavioral consequences of spreading of alpha-synuclein aggregates at the circuit level, using rodent models. The candidate is expected to integrate brain circuit mapping, targeted manipulation, and large-scale single-cell imaging with current behavioral paradigms used in Parkinson’s disease models. In addition, the successful candidate is expected to explore novel rodent behavioral tasks, informed by clinical observations in humans, that can be integrated with advanced circuit neuroscience techniques to investigate cognitive and affective deficits in Parkinson’s disease models. The approach should be holistic – broad in scope rather than restricted to a single brain region, a narrow set of behavioral assays, or a specific Parkinson’s model. The ultimate goal is to identify mechanistic underpinnings for neuronal dysfunctions that can be tested in and potentially used to treat patients.
Based on the success of the candidate’s research programme, international impact, and ability to attract external funding there are favourable options for advancement, all based on individual qualifications and necessary assessment and application procedures, as well as available funding.
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