PACE invites applications for a full-time Associate Professor / Group Leader position to join a vibrant and interdisciplinary research environment entirely focused on clinical and basic biological aspects of Parkinson’s disease and other synucleinopathies. The successful candidate will establish a collaborative research program on live-cell functional studies of alpha-synuclein aggregate processes in cell models comprising human iPSC derived neurons and glial cells, primary cultures from rodents, and organoids and tissue slices using cutting edge technologies including preformed fibrils of alpha-synuclein. Thereby, the candidate will complement and contribute to ongoing research in our established research groups investigating alpha-synuclein aggregation and their effects in the in vitro and in vivo models.
To achieve our goal, we are seeking a group leader to build a program with an emphasis on live cell imaging to gain mechanistic insight into cell autonomous and non-cell autonomous consequences of progressive build-up of alpha-synuclein aggregates in neurons and glia mechanisms involved in intercellular spreading of such processes.
The candidate is expected to develop live cell experiments of neurons and brain cells for assessing neuronal activity, organellar dynamics and function (particularly endoplasmic reticulum, mitochondria and lysosome), and synaptic activity using advanced imaging techniques along with high-content, data-driven methods based on omics. Techniques applied will comprise advanced 4D cellular and molecular imaging (e.g. lattice lightsheet SIM, genetically encoded sensors for subcellular and synaptic activities, protein-protein interactions, organellar dynamics such as mitochondrial and lysosomal functions, autophagic flux, transcription and translation). The aim should be holistic – broad in scope rather than restricted to a single cell model, a narrow set of biological readouts, or a specific Parkinson’s model.
Based on the success of the candidate’s research programme, international impact, and ability to attract external funding there are favourable options for advancement, all based on individual qualifications and necessary assessment and application procedures, as well as available funding.
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